Two European heavyweights meet in the Champions League 16 stage with Atletico Madrid hosting Juventus in Wednesday’s first leg tie. After so much recent heartbreak in this competition, Atletico are hoping to reach this year’s final which is being held at their own Wanda Metropolitano.

Juventus are looking to reach their third final in five years after losing to Barcelona in 2015 and Real Madrid in 2017.

Team news

Atletico coach Diego Simeone says Diego Costa is not fit to play the entire match. Costa returned to action last weekend after being sidelined for nearly two months because of a foot injury that required surgery.

He came off the bench in Atletico's 1-0 win at Rayo Vallecano in the Spanish league on Saturday, playing alongside Alvaro Morata for the first time.

Simeone said Tuesday that Costa "is not ready to play the 90 minutes" in the round-of-16 match at Wanda Metropolitano Stadium. 

Victor "Vitolo" Machin started against Rayo, but Simone did not give any hints about his formation for the first leg against Juventus. 

Midfielder Jorge "Koke" Resurreccion is expected to be back in the lineup after a long injury layoff, although Simeone said he will wait until Wednesday to decide whether to start him. 

Juventus coach Massimiliano Allegri says Paulo Dybala will start, but Sami Khedira has been ruled out because medical tests revealed he had an irregular heartbeat.

"Sami Khedira remained in Turin for medical examinations, after which an electrophysiology study was carried out and he underwent treatment for atrial fibrillation," said the club's statement.

Allegri started his news conference on Tuesday by announcing that Dybala would be in the starting lineup for the first leg at Atletico's Wanda Metropolitano Stadium.