PSG received a massive blow at the weekend when it was confirmed that Edinson Cavani will miss this match due to a thigh problem and may not be back in time for the return leg either.
Neymar, the world’s most expensive player, had already been ruled out because of a metatarsal issue – and he, too, is set to miss the second encounter.
Thomas Meunier is absent after sustaining a concussion at the weekend.
Although Adrien Rabiot is back training with the squad, he has not travelled.
Ex-Manchester United man Angel Di Maria is in line to start, as is Marco Verratti, though he has played only an hour following an ankle injury in January.
Possible PSG starting XI: Buffon; Kehrer, Thiago Silva, Kimpembe, Bernat; Marquinhos, Verratti; Dani Alves, Draxler, Di Maria; Mbappe
When the Champions League draw was made in December, Manchester United were strong underdogs against Paris Saint-Germain. The roles, however, have arguably been reversed, with the Premier League outfit now considered to have the edge going into this tie.
Ole Gunnar Solskjaer has revived what was previously a team ailing under Jose Mourinho, with 10 wins and a draw from 11 matches in charge.